纳米氧化铈和炎症关系的研究进展
Research progress on relationship between cerium oxide nanoparticles and inflammation
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摘要:
纳米氧化铈（CeO2NPs）是一种广泛应用的纳米稀土金属氧化物。实验研究证明，CeO2NPs具有类似于超氧化物歧化酶和过氧化氢酶的抗氧化活性，有助于缓解或减轻炎症反应，具有抗炎作用。同时，CeO2NPs能通过氧化应激反应诱导细胞毒性，具有致炎作用。本文归纳总结了CeO2NPs在不同浓度、摄入途径和粒径下与炎症的关系：CeO2NPs在机体聚集的浓度越大越容易表现出致炎作用，不同摄入途径在体内聚集的部位不同，而CeO2NPs粒径越小越容易表现出抗炎作用。
Abstract:Cerium oxide nanoparticles (CeO2NPs) are a kind of widely used nanometer rare earth metal oxide. Experimental studies show that CeO2NPs have a similar antioxidant activity with superoxide dismutase and catalase, help to alleviate or reduce inflammation, and produce an anti-inflammatory effect. At the same time, CeO2NPs have an inflammatory effect by inducing oxidative stress and then cell toxicity. This paper summarized the relationship between inflammation and CeO2NPs at different concentrations, through different intake pathways, and with different particle sizes:CeO2NPs are prone to have an inflammatory effect with a higher concentration
in vivo ; the intake pathways determine where the particles accumulate; and CeO2NPs are prone to have an anti-inflammatory effect with smaller sizes.
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