苏畅, 王志宏, 白晶, 杨慧, 吴小飞, 刘招美, 王颖琦, 王惠君, 张兵. 中国四省55岁及以上人群血清尿酸与抑郁症状的关联[J]. 环境与职业医学, 2021, 38(8): 810-816. DOI: 10.13213/j.cnki.jeom.2021.21004
引用本文: 苏畅, 王志宏, 白晶, 杨慧, 吴小飞, 刘招美, 王颖琦, 王惠君, 张兵. 中国四省55岁及以上人群血清尿酸与抑郁症状的关联[J]. 环境与职业医学, 2021, 38(8): 810-816. DOI: 10.13213/j.cnki.jeom.2021.21004
SU Chang, WANG Zhihong, BAI Jing, YANG Hui, WU Xiaofei, LIU Zhaomei, WANG Yingqi, WANG Huijun, ZHAGN Bing. Association between serum uric acid and depressive symptoms among people aged 55 years and above in four provinces of China[J]. Journal of Environmental and Occupational Medicine, 2021, 38(8): 810-816. DOI: 10.13213/j.cnki.jeom.2021.21004
Citation: SU Chang, WANG Zhihong, BAI Jing, YANG Hui, WU Xiaofei, LIU Zhaomei, WANG Yingqi, WANG Huijun, ZHAGN Bing. Association between serum uric acid and depressive symptoms among people aged 55 years and above in four provinces of China[J]. Journal of Environmental and Occupational Medicine, 2021, 38(8): 810-816. DOI: 10.13213/j.cnki.jeom.2021.21004

中国四省55岁及以上人群血清尿酸与抑郁症状的关联

Association between serum uric acid and depressive symptoms among people aged 55 years and above in four provinces of China

  • 摘要: 背景

    中老年人群血清尿酸水平与抑郁的相关研究较少且研究结果存在分歧。

    目的

    了解中老年人群血清尿酸水平与抑郁症状的关联。

    方法

    以“神经系统疾病专病社区队列研究”2018—2019年基线调查数据资料为基础,将有完整人口经济、生活方式、抑郁症状评分和血清尿酸水平数据信息的10 212名55岁及以上中老年居民作为研究对象,使用老年抑郁量表筛查来评价调查对象是否具有抑郁症状并检测空腹血清尿酸水平,计算不同特征水平下人群抑郁症状检出率及高尿酸血症患病率,采用多因素logistic回归模型分析血清尿酸水平与抑郁症状的关联程度。

    结果

    调查人群抑郁症状检出率为10.2%,其中男性为9.8%,女性为10.6%;高尿酸血症患病率为18.7%,其中男性为17.9%,女性为19.2%。男、女性尿酸平均摩尔浓度分别(341.6±89.4)、(296.2±79.8)μmol·L-1P < 0.05)。血清尿酸水平正常组的男、女性抑郁症状检出率分别为10.1%和10.3%,差异无统计学意义(P>0.05);血清尿酸过高组的男、女性抑郁症状检出率分别为8.7%和11.6%,差异具有统计学意义(P < 0.05)。无抑郁症状组的男、女性高尿酸血症患病率分别为18.2%和19.0%,差异无统计学意义(P>0.05);有抑郁症状组的男、女性高尿酸血症患病率分别为15.8%和21.2%,差异具有统计学意义(P < 0.05)。logistic回归模型分析结果显示,与男性血清尿酸水平最低五分位组的人群相比,最高五分位组人群出现抑郁症状的风险降低(OR=0.69,95%CI:0.49~0.98)。

    结论

    血清尿酸水平正常的人群抑郁症状检出率不存在性别差异,血清尿酸水平过高人群中女性的抑郁症状检出率更高。男性中老年人群血清尿酸水平与抑郁症状存在负相关。

     

    Abstract: Background

    There are limited studies on the correlation between serum uric acid levels and depressive symptoms in middle-aged and elderly populations, and the study results are inconsistent.

    Objective

    This study is designed to investigate the association between serum uric acid levels and depressive symptoms in a middle-aged and elderly population.

    Methods

    Based on the 2018-2019 baseline data of the Community-based Cohort Study on Nervous System Diseases, a total of 10 212 people aged 55 years and above with complete demographic, lifestyle, depressive symptom score, and serum uric acid data were selected as study subjects. The Geriatric Depression Scale was used to evaluate whether the respondents had depressive symptoms, and fasting serum uric acid levels were tested at the same time. The positive rate of depressive symptoms and the prevalence rate of hyperuricemia in the population by different characteristics were calculated. The association between serum uric acid levels and depressive symptoms was analyzed using a multiple logistic regression model.

    Results

    The positive rate of depressive symptoms in the overall study population was 10.2%, 9.8% in men and 10.6% in women, respectively. The prevalence rate of hyperuricemia in the overall study population was 18.7%, 17.9% in men and 19.2% in women, respectively. The concentrations of serum uric acid in male and female were (341.6±89.4) and (296.2±79.8) μmol·L-1 respectively (P < 0.05). There was no significant difference in the positive rate of depressive symptoms between male (10.1%) and female (10.3%) with a normal serum uric acid level (P>0.05). The positive of depressive symptoms in male (8.7%) was significantly lower than that in female (11.6%) with an excessive serum uric acid level (P < 0.05). In participants without depressive symptoms, there was no significant difference in the prevalence rate of hyperuricemia in male (18.2%) and female (19.0%) (P>0.05). However, in participants with depressive symptoms, the prevalence rate of hyperuricemia in male (15.8%) was significantly lower than that in female (21.2%) (P < 0.05). The logistic regression analysis results showed that the risk of depressive symptoms in the highest quintile group of serum uric acid level was significantly lower than that in the lowest quintile group in male (OR=0.69, 95%CI: 0.49-0.98).

    Conclusion

    No gender difference in the positive rate of depressive symptoms is found in the population with a normal serum uric acid level, but women with an excessive serum uric acid level have a higher positive rate of depressive symptoms. There is a negative correlation between serum uric acid levels and depressive symptoms in the middle-aged and elderly male population.

     

/

返回文章
返回