张博雅, 许雨柔, 张济明, 郭剑秋, 齐小娟, 吕沈亮, 常秀丽, 邬春华, 周志俊. 孕期毒死蜱暴露水平与新生儿体格发育指标的关系[J]. 环境与职业医学, 2021, 38(9): 930-935. DOI: 10.13213/j.cnki.jeom.2021.21131
引用本文: 张博雅, 许雨柔, 张济明, 郭剑秋, 齐小娟, 吕沈亮, 常秀丽, 邬春华, 周志俊. 孕期毒死蜱暴露水平与新生儿体格发育指标的关系[J]. 环境与职业医学, 2021, 38(9): 930-935. DOI: 10.13213/j.cnki.jeom.2021.21131
ZHANG Boya, XU Yurou, ZHANG Jiming, GUO Jianqiu, QI Xiaojuan, LYU Shenliang, CHANG Xiuli, WU Chunhua, ZHOU Zhijun. Relationship between chlorpyrifos exposure level in pregnancy and neonatal anthropometric indices at birth[J]. Journal of Environmental and Occupational Medicine, 2021, 38(9): 930-935. DOI: 10.13213/j.cnki.jeom.2021.21131
Citation: ZHANG Boya, XU Yurou, ZHANG Jiming, GUO Jianqiu, QI Xiaojuan, LYU Shenliang, CHANG Xiuli, WU Chunhua, ZHOU Zhijun. Relationship between chlorpyrifos exposure level in pregnancy and neonatal anthropometric indices at birth[J]. Journal of Environmental and Occupational Medicine, 2021, 38(9): 930-935. DOI: 10.13213/j.cnki.jeom.2021.21131

孕期毒死蜱暴露水平与新生儿体格发育指标的关系

Relationship between chlorpyrifos exposure level in pregnancy and neonatal anthropometric indices at birth

  • 摘要: 背景

    农药毒死蜱(CPF)广泛应用于农业生产,由此造成的环境污染和人群健康风险受到重视。

    目的

    探究母亲孕期CPF暴露水平与新生儿体格发育指标的关系。

    方法

    以江苏射阳小型出生队列1100对母子对为研究对象。由专业助产人员测量新生儿身长、头围和出生体重,计算体重指数(BMI)和重量指数(PI)。通过问卷调查孕妇的一般人口学特征和孕期信息,并采集孕妇产前尿样,采用气相质谱法测定孕妇尿样中CPF特异性代谢物3,5,6- 三氯-2- 吡啶醇(TCPy)浓度评估孕妇尿中毒死蜱暴露水平,并采用广义线性模型评估孕妇暴露水平与新生儿体格发育指标及巨大儿发生风险的关系。

    结果

    本研究中孕妇尿中TCPy检出率为100%,TCPy肌酐校正浓度范围为0.14~135.44 μg·g-1(以肌酐计,后同),中位数M及第25、75百分位数(P25P75)为6.96(4.35,11.75)μg·g-1,几何均值7.02 μg·g-1;新生儿的出生体重、身长、头围、BMI、PI分别为(3 490.49±442.57)g、(51.23±2.35)cm、(34.64±1.45)cm、(13.29±1.41)kg·m-2、(2.60±0.32)g·cm-3,其中巨大儿137例(12.5%),本研究发现孕期TCPy水平与新生儿PI 回归系数(b)=0.062,95% CI:0.012~0.112,P=0.016、BMI b(95% CI):0.270(0.053~0.486),P=0.015呈正相关。身长(P=0.088)、BMI(P=0.033)、PI(P=0.013)模型性别交互项P值均小于交互项检验水准(α=0.10)。性别分层后,孕妇尿中TCPy水平与男性新生儿的PI b(95% CI):0.111(0.043~0.179),P=0.001、BMI b(95% CI):0.443(0.138~0.748),P=0.004正相关;而在女性新生儿中上述指标的相关均无统计学意义(P > 0.05)。

    结论

    孕期CPF暴露可能影响宫内发育过程,且其健康效应可能具有性别差异。

     

    Abstract: Background

    The organophosphorus pesticide chlorpyrifos (CPF) is widely used in agricultural production, and the resulting environmental pollution and health risk are serious concerns.

    Objective

    This study aims to investigate the relationship between CPF exposure level in pregnancy and anthropometric indices of newborns at birth.

    Methods

    A total of 1 100 mother-child pairs in Jiangsu Sheyang Mini Birth Cohort Study were enrolled as study subjects. Length, head circumference, and birth weight of the newborns were measured by professional midwives, and body mass index (BMI) and ponderal index (PI) were calculated. A questionnaire survey was conducted to collected maternal socio-demographic characteristics and pregnancy variables. Spot urine samples were collected during pregnancy. Maternal urinary concentrations of 3, 5, 6-trichloro-2-pyridinol (TCPy, a specific metabolite of CPF) were measured by gas chromatography tandem mass spectrometry. Generalized linear models were used to evaluate the relationships of prenatal exposure to TCPy with anthropometric indices and the risk of macrosomia.

    Results

    TCPy was detected in all maternal urine samples. The creatinine-adjusted TCPy levels ranged from 0.14 to 135.44 μg·g-1, the median (P25, P75) was 6.96 (4.35, 11.75) μg·g-1, and the geometric mean was 7.02 μg·g-1. The birth weight, body length, head circumference, BMI, and PI of the newborns were (3 490.49±442.57) g, (51.23±2.35) cm, (34.64±1.45) cm, (13.29±1.41) kg·m-2, and (2.60±0.32) g·cm-3, respectively. There were 137 macrosomia cases (12.5%). The results of generalized linear model indicated that the prenatal TCPy level was positively associated with the PI b (95% CI): 0.062 (0.012-0.112), P=0.016 and BMI b (95% CI): 0.270 (0.053-0.486), P=0.015. The P values for sex-interaction were all lower than the level of significance (α=0.10) for body length (P=0.088), BMI (P=0.033), PI (P=0.013) models. In the sex-stratified analysis, the TCPy level was positively associated with PI and BMI in boys b (95% CI): 0.111 (0.043-0.179), P=0.001; b (95% CI): 0.443 (0.138-0.748), P=0.001, but no associations were found in girls (P > 0.05).

    Conclusion

    Prenatal CPF exposure may affect intrauterine development, and this health effect may have sex differences.

     

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