ZHAO Jin-hui, LIU Yang. Research progress on relationship between cerium oxide nanoparticles and inflammation[J]. Journal of Environmental and Occupational Medicine, 2020, 37(12): 1239-1243. DOI: 10.13213/j.cnki.jeom.2020.20355
Citation: ZHAO Jin-hui, LIU Yang. Research progress on relationship between cerium oxide nanoparticles and inflammation[J]. Journal of Environmental and Occupational Medicine, 2020, 37(12): 1239-1243. DOI: 10.13213/j.cnki.jeom.2020.20355

Research progress on relationship between cerium oxide nanoparticles and inflammation

  • Cerium oxide nanoparticles (CeO2NPs) are a kind of widely used nanometer rare earth metal oxide. Experimental studies show that CeO2NPs have a similar antioxidant activity with superoxide dismutase and catalase, help to alleviate or reduce inflammation, and produce an anti-inflammatory effect. At the same time, CeO2NPs have an inflammatory effect by inducing oxidative stress and then cell toxicity. This paper summarized the relationship between inflammation and CeO2NPs at different concentrations, through different intake pathways, and with different particle sizes:CeO2NPs are prone to have an inflammatory effect with a higher concentration in vivo; the intake pathways determine where the particles accumulate; and CeO2NPs are prone to have an anti-inflammatory effect with smaller sizes.
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