冯涓, 刘卫花, 钱怡, 胡博骅, 吕懿, 张文平, 仇玉兰, 王偃倩, 唐仕川, 郑金平. 纳米碳酸钙对职业暴露人群的血液和心血管系统的影响[J]. 环境与职业医学, 2014, 31(5): 377-380. DOI: 10.13213/j.cnki.jeom.2014.0084
引用本文: 冯涓, 刘卫花, 钱怡, 胡博骅, 吕懿, 张文平, 仇玉兰, 王偃倩, 唐仕川, 郑金平. 纳米碳酸钙对职业暴露人群的血液和心血管系统的影响[J]. 环境与职业医学, 2014, 31(5): 377-380. DOI: 10.13213/j.cnki.jeom.2014.0084
FENG Juan , LIU Wei-hua , QIAN Yi , HU Bo-hua , LÜ Yi , ZHANG Wen-ping , QIU Yu-lan , WANG Yanqian , TANG Shi-chuan , ZHENG Jin-ping . Effects of Occupational Exposure to Nano-CaCO3 on Hematological and Cardiovascular Systems[J]. Journal of Environmental and Occupational Medicine, 2014, 31(5): 377-380. DOI: 10.13213/j.cnki.jeom.2014.0084
Citation: FENG Juan , LIU Wei-hua , QIAN Yi , HU Bo-hua , LÜ Yi , ZHANG Wen-ping , QIU Yu-lan , WANG Yanqian , TANG Shi-chuan , ZHENG Jin-ping . Effects of Occupational Exposure to Nano-CaCO3 on Hematological and Cardiovascular Systems[J]. Journal of Environmental and Occupational Medicine, 2014, 31(5): 377-380. DOI: 10.13213/j.cnki.jeom.2014.0084

纳米碳酸钙对职业暴露人群的血液和心血管系统的影响

Effects of Occupational Exposure to Nano-CaCO3 on Hematological and Cardiovascular Systems

  • 摘要: 目的 初步探讨纳米碳酸钙对职业暴露人群的血液和心血管系统的影响。

    方法 选取山西某纳米碳酸钙厂129名工人为暴露组,当地某医院60名后勤职工为对照组。收集个人基本信息,对研究人群进行常规体检。

    结果 暴露组工人高血压患病率、心率和心电图异常率分别为30.23%、17.83%和44.96%,高于对照组(分别为13.33%、6.67%和6.67%) (P<0.05)。与对照组相比,暴露组工人血液中血红蛋白、红细胞计数、红细胞压积、平均红细胞容积、平均红细胞血红蛋白、平均红细胞血红蛋白浓度、红细胞分布宽度变异系数、淋巴细胞百分比、中性粒细胞百分比、总胆红素和间接胆红素的异常率均高于对照组(P<0.05)。多元线性回归分析显示,纳米碳酸钙暴露与工人血液中淋巴细胞数目、平均红细胞血红蛋白浓度、平均血小板体积、血小板分布宽度、总胆红素和间接胆红素呈正相关。工龄与工人血液中血红蛋白和红细胞压积呈负相关。暴露和工龄分别与平均红细胞体积和平均红细胞血红蛋白含量呈正相关。logistic回归分析结果显示,纳米碳酸钙暴露是调查人群高血压患病和心电图异常的主要危险因素(分别为OR=5.118, P<0.05; OR=17.736, P<0.05)。

    结论 纳米碳酸钙对职业暴露人群的血液和心血管系统有一定影响。

     

    Abstract: Objective To examine the effects of nano-CaCO3 on hematological and cardiovascular systems in an occupational population.

    Methods A total of 129 workers from a nano-CaCO3 plant of Shanxi Province were selected as an exposure group, and 60 staff of a hospital in the same county were selected as a control group. General information of the participants were collected by questionnaires, and routine physical examinations were performed.

    Results The prevalence rate of hypertension was 30.23%, and the abnormal rates of heart rate and electrocardiogram (ECG) were 17.83% and 44.96% respectively in the exposure group, which were significantly higher than those in the control group (13.33%, 6.67%, and 6.67% respectively, P<0.05). The abnormal rate of hemoglobin, number of red blood cells, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width coefficient of variation, percentage of lymphocytes, percentage of neutrophilic granulocyte, total bilirubin, and indirect bilirubin in the exposure group were significantly higher than those in the control group (P<0.05). The results of multiple linear regression analysis showed that nano-CaCO3 exposure was positively associated with lymphocytes, mean corpuscular hemoglobin concentration, mean platelet volume, platelet distribution width, total bilirubin, and indirect bilirubin. Length of service was negatively associated with hemoglobin and hematocrit. Exposure and length of service were positively associated with mean corpuscular volume and mean corpuscular hemoglobin. The results of logistic regression analysis showed that the nano-CaCO3 exposure was a major risk factor for hypertension and abnormalities of the ECG (OR=5.118, P<0.05; OR=17.736, P<0.05).

    Conclusion Nano-CaCO3 could influence the hematological and cardiovascular systems of occupationally exposed populations.

     

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