梁婧, 于贵新, 罗虎, 常晓燕. 职业人群血清丙氨酸氨基转移酶参考区间的探讨[J]. 环境与职业医学, 2015, 32(1): 47-50. DOI: 10.13213/j.cnki.jeom.2015.14164
引用本文: 梁婧, 于贵新, 罗虎, 常晓燕. 职业人群血清丙氨酸氨基转移酶参考区间的探讨[J]. 环境与职业医学, 2015, 32(1): 47-50. DOI: 10.13213/j.cnki.jeom.2015.14164
LIANG Jing , YU Gui-xin , LUO Hu , CHANG Xiao-yan . Reference Range of Serum Alanine Aminotransferase in Occupational Populations[J]. Journal of Environmental and Occupational Medicine, 2015, 32(1): 47-50. DOI: 10.13213/j.cnki.jeom.2015.14164
Citation: LIANG Jing , YU Gui-xin , LUO Hu , CHANG Xiao-yan . Reference Range of Serum Alanine Aminotransferase in Occupational Populations[J]. Journal of Environmental and Occupational Medicine, 2015, 32(1): 47-50. DOI: 10.13213/j.cnki.jeom.2015.14164

职业人群血清丙氨酸氨基转移酶参考区间的探讨

Reference Range of Serum Alanine Aminotransferase in Occupational Populations

  • 摘要: 目的 探讨职业性有害因素接触人群的血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)的参考区间,为相应卫生标准的制定提供基础数据。

    方法 选取2013年1月1日-2013年12月31日至北京市预防医学研究中心职业卫生所进行职业健康检查、接触职业性肝损伤有害因素的2 023名在岗工人的职业健康检查资料进行回顾性研究。采用全自动生化分析仪进行血清ALT检测,采用腹部B超常规检查探查肝脏实质及肝内血管疾患情况,并进行统计分析。

    结果 目标人群血清ALT水平为18 U/L (17 U/L,216 U/L),不同性别和年龄之间的血清ALT值差异具有统计学意义(P<0.05)。排除肝脏器质性疾患的个体后,该职业人群中男性工人血清ALT值的单侧95%范围为5.0~62.2U/L,高于现行标准(2013-08-01之前)(5~40 U/L)。血清ALT水平在41~60 U/L之间的男性工人的肝脏B超检查阳性率同血清ALT值> 61 U/L的男性工人相比较,差异无统计学意义。

    结论 职业人群中男性血清ALT值的参考区间可参考卫生部制定的新标准。

     

    Abstract: Objective To explore the reference range of serum alanine aminotransferase (ALT) in populations with exposure to occupational hazards, and to provide theoretical basis for the development of related hygienic standards.

    Methods Occupational physical examination records of 2 023 workers exposed to occupational hazards having hepatotoxic potentials and ordered occupational health examinations in Institute of Occupational Health, Beijing Center for Diseases Prevention and Control from 1 January to 31 December 2013 were retrieved for retrospective analysis. Serum ALT was measured by automatic biochemistry analyzer. Liver and intrahepatic vascular diseases were detected by abdomen B-ultrasound examination. Then statistical analysis was applied.

    Results The average serum ALT value was 18 U/L (17 U/L, 216 U/L) in the population, and there were significant differences among different genders and ages. Excluding those having organic liver diseases, the unilateral 95% range for male serum ALT value was 5.0-62.2 U/L, higher than the current standard (before 1 August 2013) (5-40 U/L). However, the positive rate of B-ultrasound examination in the male workers with serum ALT values within 41-60 U/L versus greater than 61 U/L was not significantly different.

    Conclusion The reference range of serum ALT in the male occupational population may refer to the new standard publicized by Ministry of Health.

     

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