温忆敏, 沈朝烨, 梁卫玖, 杨文慧, 朱怡平, 林元杰. 工作场所空气中1,6-己二异氰酸酯的吸收液衍生-液相色谱检测方法[J]. 环境与职业医学, 2015, 32(5): 481-485. DOI: 10.13213/j.cnki.jeom.2015.14606
引用本文: 温忆敏, 沈朝烨, 梁卫玖, 杨文慧, 朱怡平, 林元杰. 工作场所空气中1,6-己二异氰酸酯的吸收液衍生-液相色谱检测方法[J]. 环境与职业医学, 2015, 32(5): 481-485. DOI: 10.13213/j.cnki.jeom.2015.14606
WEN Yi-min , SHEN Chao-ye , LIANG Wei-jiu , YANG Wen-hui , ZHU Yi-ping , LIN Yuan-jie . Determination of Hexamethylene Diisocyanate in Workplace Air by Derivatization with Absorbing Liquid and Liquid Chromatography[J]. Journal of Environmental and Occupational Medicine, 2015, 32(5): 481-485. DOI: 10.13213/j.cnki.jeom.2015.14606
Citation: WEN Yi-min , SHEN Chao-ye , LIANG Wei-jiu , YANG Wen-hui , ZHU Yi-ping , LIN Yuan-jie . Determination of Hexamethylene Diisocyanate in Workplace Air by Derivatization with Absorbing Liquid and Liquid Chromatography[J]. Journal of Environmental and Occupational Medicine, 2015, 32(5): 481-485. DOI: 10.13213/j.cnki.jeom.2015.14606

工作场所空气中1,6-己二异氰酸酯的吸收液衍生-液相色谱检测方法

Determination of Hexamethylene Diisocyanate in Workplace Air by Derivatization with Absorbing Liquid and Liquid Chromatography

  • 摘要: 目的 建立工作场所空气中1,6-己二异氰酸酯(HDI)的吸收液衍生-液相色谱检测方法。

    方法 样品采用冲击式采样管,色胺/二甲亚砜吸收液采样并衍生,高效液相色谱测定HDI衍生物浓度。

    结果 该方法在0.050~10μg/mL范围内呈线性良好,回归方程& #375;=6.9& #215;106x-4.6& #215;104,相关系数r=1.000。当采样体积为45 L时,HDI最低检出浓度为0.00054 mg/m3,最低定量浓度为0.0018 mg/m3。采样后的吸收液常温下可长期保存,14 d的下降率小于5%。工作场所空气中可能存在的其他异氰酸酯类化合物等,在该方法条件下对测定结果无干扰。

    结论 该方法适用于工作场所空气中HDI的日常监测。

     

    Abstract: Objective To establish a detection method for hexamethylene diisocyanate (HDI) in workplace air by derivatization with absorbing liquid and liquid chromatography.

    Methods Air samples were collected with impinger and absorbing liquid (tryptamine/dimethylsulfoxide) for derivatization.The HDI derivative concentration was detected by high performance liquid chromatography.

    Results The method showed a good linearity within the range of 0.050-10 μg/mL with the regression equation& #375;=6.9& #215;106x-4.6& #215;104 and the correlation coefficient r=1.000.The limit of detection and limit of quantitation of HDI were 0.000 54 mg/m3 and 0.001 8 mg/m3 respectively when the sampling volume was 45 L.The absorption liquid could be kept for long time under normal temperature after sampling,as the degradation rate was less than 5% after 14 days.Other derivatives of isocyanates in workplace air did not interfere with the determination.

    Conclusion The method is suitable for the routine monitoring of HDI in workplace air.

     

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