Abstract: Flurochloridone (FLC) is a kind of pyrrolidone selective pre-emergence herbicide, mainly applied to corns, sunflowers, and potatoes to prevent and control broadleaf and gramineous weeds. Similar herbicides include norflurazon, fluridone, diflufenican, and so on. In 2010, the European Food Safety Authority (EFSA) published a risk assessment report on FLC. This paper focused on the latest information of the risk assessment report and the research progress on FLC biological toxicity in recent years.