To explore the risk factors of children and teenagers' injury, and to provide scientific evidence to related organizations for making prevention strategies.

RevMan 5.1 software was employed to perform a quantitative analysis on 25 Chinese literatures.

Fixed and random effect models were employed to combine the ORs and 95%CIs of the risk factors derived from each literature. The results showed that myopia (OR=1.36), being active (OR=1.27), not nuclear family (OR=1.24 for primary and junior high school students, OR=1.80 for junior and senior high school students, and OR=4.46 for children aged 0-14 years), boy (OR=1.46), younger age (OR=1.16), being ignorant of preventability of injury (OR=1.56), risk behaviors (OR=1.28), extroverts (OR=1.48 for primary and junior high school students, OR=5.47 for junior and senior high school students, and OR=1.52 for children aged 0-14 years), being left-handed (OR=1.65), no safety education (OR=2.61), risk environments (OR=1.80), and having sibling(s) (OR=1.98) were the risk factors of children and teenagers' injury, and the differences were statistically significant (P < 0.05). Urban residence, low education level of mother, poor school performance, tense family relationship, and fathers' smoking habits were not considered as risk factors, and the differences were not statistically significant (P > 0.05).

The analysis of 25 literatures indicates 12 risk factors for children and teenager's injury, and there are not enough evidence yet for other 5 factors.