冯婧, 田晓琳, 董妮莎, 张飞, 王璐, 宋国华, 陈朝阳, 阎小艳. 氟致内质网应激性凋亡的研究进展[J]. 环境与职业医学, 2018, 35(6): 566-571. DOI: 10.13213/j.cnki.jeom.2018.17759
引用本文: 冯婧, 田晓琳, 董妮莎, 张飞, 王璐, 宋国华, 陈朝阳, 阎小艳. 氟致内质网应激性凋亡的研究进展[J]. 环境与职业医学, 2018, 35(6): 566-571. DOI: 10.13213/j.cnki.jeom.2018.17759
FENG Jinga, TIAN Xiao-lina, DONG Ni-shab, ZHANG Feib, WANG Lua, SONG Guo-huaa, CHEN Zhao-yanga, YAN Xiao-yanb. Research progress on endoplasmic reticulum stress-induced apoptosis caused by fluorine[J]. Journal of Environmental and Occupational Medicine, 2018, 35(6): 566-571. DOI: 10.13213/j.cnki.jeom.2018.17759
Citation: FENG Jinga, TIAN Xiao-lina, DONG Ni-shab, ZHANG Feib, WANG Lua, SONG Guo-huaa, CHEN Zhao-yanga, YAN Xiao-yanb. Research progress on endoplasmic reticulum stress-induced apoptosis caused by fluorine[J]. Journal of Environmental and Occupational Medicine, 2018, 35(6): 566-571. DOI: 10.13213/j.cnki.jeom.2018.17759

氟致内质网应激性凋亡的研究进展

Research progress on endoplasmic reticulum stress-induced apoptosis caused by fluorine

  • 摘要: 氟中毒会诱发细胞凋亡, 引起骨相和非骨相组织损伤, 从而影响人体健康, 但其作用机制尚不明确。目前研究显示, 内质网应激诱导的细胞凋亡可能与氟致机体各系统损伤有关。本文叙述了内质网应激的发生、未折叠蛋白反应的三条通路、内质网应激性凋亡在氟致机体损伤中的作用, 得出内质网应激主要通过诱导细胞凋亡在氟致机体损伤中发挥作用的观点。

     

    Abstract: Fluorosis can induce cell apoptosis and cause damage to bone and non-bone tissues, which affects human health, but relevant mechanism is not clear yet.Available studies have shown that the apoptosis induced by endoplasmic reticulum stress may be related to the potential mechanism of fluorosis.This article described the occurrence of endoplasmic reticulum stress, three unfolded protein reaction pathways, and the role of endoplasmic reticulum stress-related apoptosis in the potential mechanism of fluorine-induced damage, concluding that endoplasmic reticulum stress played a role in fluorosis via inducing apoptosis.

     

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