李丹, 马明月. 双酚A对精子发生影响及机制的研究进展[J]. 环境与职业医学, 2019, 36(3): 272-276. DOI: 10.13213/j.cnki.jeom.2019.18466
引用本文: 李丹, 马明月. 双酚A对精子发生影响及机制的研究进展[J]. 环境与职业医学, 2019, 36(3): 272-276. DOI: 10.13213/j.cnki.jeom.2019.18466
LI Dan, MA Ming-yue. Research progress on effects and mechanisms of bisphenol A on spermatogenesis[J]. Journal of Environmental and Occupational Medicine, 2019, 36(3): 272-276. DOI: 10.13213/j.cnki.jeom.2019.18466
Citation: LI Dan, MA Ming-yue. Research progress on effects and mechanisms of bisphenol A on spermatogenesis[J]. Journal of Environmental and Occupational Medicine, 2019, 36(3): 272-276. DOI: 10.13213/j.cnki.jeom.2019.18466

双酚A对精子发生影响及机制的研究进展

Research progress on effects and mechanisms of bisphenol A on spermatogenesis

  • 摘要: 双酚A(BPA)是一种环境内分泌干扰物,主要用于日常用品中聚碳酸酯塑料和环氧树脂的制造,人们可以通过皮肤、饮水、饮食等途径接触BPA。大量动物实验和人群研究证实BPA暴露可以对男性生殖功能产生不利的影响,包括精子发生、精子质量,甚至影响后代的生殖功能。但是BPA对雄性生殖影响的机制尚不清楚。本文介绍了BPA的暴露情况、BPA对睾丸和附睾以及对精子发生过程的影响及相关机制,得出BPA通过在精子发生的不同阶段损伤精原干细胞、各级精细胞,影响激素分泌,从而减少精子数量及干扰精子的成熟。因此,在发育的关键时期应减少和避免BPA暴露,以保障男性生殖系统的正常发育。最后,本文提出建立精准的孕期暴露体内实验模型、体外细胞分子机制研究、开展更为广泛的流行病学研究是未来研究的主要方向。

     

    Abstract: Bisphenol A (BPA) is an environmental endocrine disruptor mainly used in the manufacture of polycarbonate plastics, epoxy resins, and a variety of everyday products. People are exposed to BPA through skin, water, and diet. A large number of animal experiments and population studies have confirmed that BPA has adverse effects on male reproductive function, such as spermatogenesis and sperm quality, and even the reproductive function of offspring. However, the mechanism of BPA male reproductive toxicity is still not clear. This paper introduced the status of BPA exposure, the effects of BPA on testis, epididymis, and spermatogenesis, and the related mechanisms; concluded that BPA could reduce sperm quantity and interfere with sperm maturation by damaging spermatogonial stem cells and sperm cells at different stages of spermatogenesis and affecting hormone secretion. Therefore, the review pointed out that reducing and avoiding BPA exposure during critical period of development would ensure the development of male reproductive system. Future research directions should include establishing in vivo experimental models with accurate exposure during pregnancy, studying the cellular and molecular mechanisms in vitro, and carrying out more extensive epidemiological studies.

     

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