朱华龙, 熊永伟, 王华. 镉对胚胎/胎儿发育的损害作用及其机制[J]. 环境与职业医学, 2019, 36(2): 151-156. DOI: 10.13213/j.cnki.jeom.2019.18639
引用本文: 朱华龙, 熊永伟, 王华. 镉对胚胎/胎儿发育的损害作用及其机制[J]. 环境与职业医学, 2019, 36(2): 151-156. DOI: 10.13213/j.cnki.jeom.2019.18639
ZHU Hua-long, XIONG Yong-wei, WANG Hua. Adverse effects of cadmium on embryonic and fetal development and its mechanism[J]. Journal of Environmental and Occupational Medicine, 2019, 36(2): 151-156. DOI: 10.13213/j.cnki.jeom.2019.18639
Citation: ZHU Hua-long, XIONG Yong-wei, WANG Hua. Adverse effects of cadmium on embryonic and fetal development and its mechanism[J]. Journal of Environmental and Occupational Medicine, 2019, 36(2): 151-156. DOI: 10.13213/j.cnki.jeom.2019.18639

镉对胚胎/胎儿发育的损害作用及其机制

Adverse effects of cadmium on embryonic and fetal development and its mechanism

  • 摘要: 镉对生态环境和人群健康的危害受到广泛关注。以往研究主要关注成年期镉暴露对肝脏、肾脏、肺脏、大脑和睾丸等脏器的损害作用,但对子代及其远期损害作用的研究甚少。近年来,孕期母体环境镉暴露与胚胎/胎儿发育损伤的关联研究已成为当前重要的公共卫生问题,镉的发育毒性作用及其机制已有大量研究报道。众多研究资料显示,孕期母体镉暴露能够引起胚胎/胎儿死亡、胎儿畸形和胎儿生长受限等。此外,出生前镉暴露还可以引起子代智力低下、情感障碍、心血管疾病、雄性生殖障碍等慢性疾病高发。镉引起胚胎/胎儿发育损伤的机制主要包括母源性机制、胎盘机制和胎儿损伤机制等。因此,本文着重综述了镉对胚胎/胎儿发育的损害作用及其机制的研究进展。

     

    Abstract: The adverse effects of cadmium on ecosystem and human health have attracted worldwide attention. Previous studies have focused mainly on the toxic effects of cadmium exposure in adulthood on liver, kidney, lung, brain, and testis; however, there are few studies on progeny and its long-term effects. Recently, the association between maternal cadmium exposure during pregnancy and embryonic/fetal dysplasia has become a hot topic in public health as a lot of studies have reported cadmium-induced developmental toxicity and its mechanism. Other studies have shown that maternal cadmium exposure during pregnancy can cause fetal death, fetal malformation, and fetal growth restriction. In addition, prenatal cadmium exposure can lead to lower IQ, mood disorders, cardiovascular diseases, male reproductive impairments, and other chronic diseases. The mechanisms of cadmium causing embryonic/fetal development injury mainly include maternal mechanism, placental mechanism, and fetal injury mechanism. Therefore, the adverse effects of cadmium on embryonic and fetal development and its mechanism were summarized in this review.

     

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