许仲妍, 谢嘉渝, 田震, 梁婷婷, 陈维娜, 李雪莹, 王瑜阳, 张慧东. RNA的m6A修饰在女性生殖健康中的作用和机制[J]. 环境与职业医学, 2019, 36(3): 226-231. DOI: 10.13213/j.cnki.jeom.2019.18678
引用本文: 许仲妍, 谢嘉渝, 田震, 梁婷婷, 陈维娜, 李雪莹, 王瑜阳, 张慧东. RNA的m6A修饰在女性生殖健康中的作用和机制[J]. 环境与职业医学, 2019, 36(3): 226-231. DOI: 10.13213/j.cnki.jeom.2019.18678
XU Zhong-yan, XIE Jia-yu, TIAN Zhen, LIANG Ting-ting, CHEN Wei-na, LI Xue-ying, WANG Yu-yang, ZHANG Huidong. Roles and mechanisms of RNA m6A modification in female reproductive health[J]. Journal of Environmental and Occupational Medicine, 2019, 36(3): 226-231. DOI: 10.13213/j.cnki.jeom.2019.18678
Citation: XU Zhong-yan, XIE Jia-yu, TIAN Zhen, LIANG Ting-ting, CHEN Wei-na, LI Xue-ying, WANG Yu-yang, ZHANG Huidong. Roles and mechanisms of RNA m6A modification in female reproductive health[J]. Journal of Environmental and Occupational Medicine, 2019, 36(3): 226-231. DOI: 10.13213/j.cnki.jeom.2019.18678

RNA的m6A修饰在女性生殖健康中的作用和机制

Roles and mechanisms of RNA m6A modification in female reproductive health

  • 摘要: 女性生殖健康越来越受到重视,对其影响因素的研究也逐渐增多。表观遗传现象N6-甲基腺嘌呤(N6-methyladenosine,m6A)是一种在细胞内动态可逆并调控各种生命过程的RNA修饰。近年来,越来越多的研究表明其与女性生殖疾病密切相关,进而影响女性生殖健康。本文综述了RNA的m6A修饰在女性生殖过程中的作用和机制,介绍了m6A RNA通过甲基转移酶、脱甲基酶或甲基结合蛋白调控生殖发育过程,包括卵母细胞成熟过程以及胚胎发育中神经系统、肌肉发生、造血系统等的发育过程,且与卵巢早衰和宫颈癌相关。随着RNA表观转录组学研究的发展,目前对m6A修饰的研究由单一的生殖功能研究转向兼顾机制、功能以及与疾病关联性的研究,但m6A RNA在环境/职业因素所致女性生殖健康危害中的作用及机制方面研究尚显不足。m6A RNA可能作为新的生物标志和临床治疗靶点,为保障女性生殖健康提供新思路。

     

    Abstract: Female reproductive health has received increasing attention, and studies on its influencing factors have also gradually increased. Epigenetic phenomenon N6-methyladenosine (m6A) is a RNA modification that is dynamically reversible within cells and regulates various life processes. In recent years, more and more studies have shown that it is closely related to female reproductive diseases, which in turn affects women's reproductive health. This review summarized the proposed roles and mechanisms of m6A modification in female reproductive process, and introduced m6A RNA regulation of reproductive and development process through methyltransferase, demethylase, or methyl binding protein, including oocyte maturation and the embryonic development of nervous system, myogenesis, and hematopoietic system, as well as its association with premature ovarian failure and cervical cancer. This paper pointed out that with the development of RNA epitranscriptomics, studies on m6A modification have shifted from a single reproductive function to a combination of mechanisms, functions, and associations with diseases; however, studies on the roles and mechanisms of m6A RNA in female reproductive health hazards due to environmental or occupational factors are still insufficient. m6A RNA may serve as a new biomarker and clinical therapeutic target, providing new ideas for protecting female reproductive health.

     

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