闫梦薇, 白易, 王德军, 陈田. 多溴二苯醚对甲状腺激素的影响及其机制研究进展[J]. 环境与职业医学, 2019, 36(10): 979-987. DOI: 10.13213/j.cnki.jeom.2019.19045
引用本文: 闫梦薇, 白易, 王德军, 陈田. 多溴二苯醚对甲状腺激素的影响及其机制研究进展[J]. 环境与职业医学, 2019, 36(10): 979-987. DOI: 10.13213/j.cnki.jeom.2019.19045
YAN Meng-wei, BAI Yi, WANG De-jun, CHEN Tian. A review on disruption of thyroid hormones caused by polybrominated diphenyl ethers and associated mechanism[J]. Journal of Environmental and Occupational Medicine, 2019, 36(10): 979-987. DOI: 10.13213/j.cnki.jeom.2019.19045
Citation: YAN Meng-wei, BAI Yi, WANG De-jun, CHEN Tian. A review on disruption of thyroid hormones caused by polybrominated diphenyl ethers and associated mechanism[J]. Journal of Environmental and Occupational Medicine, 2019, 36(10): 979-987. DOI: 10.13213/j.cnki.jeom.2019.19045

多溴二苯醚对甲状腺激素的影响及其机制研究进展

A review on disruption of thyroid hormones caused by polybrominated diphenyl ethers and associated mechanism

  • 摘要: 多溴二苯醚(PBDEs)作为添加型阻燃剂广泛应用于电子设备、塑料制品、建筑材料等,有证据表明PBDEs是一种持久性有机污染物。由于PBDEs与甲状腺激素(THs)在化学结构上相似,其对甲状腺激素的干扰效应也引起了广泛的关注。本综述总结了PBDEs对人体THs干扰的人群流行病学研究数据,表明PBDEs暴露很可能会干扰THs的稳态,但不同的研究显示出了不同的结果,这可能与其干扰机制息息相关。故本综述从THs的合成分泌、血液中的转运、活化和代谢以及下丘脑-垂体-甲状腺激素轴四方面分析了PBDEs及其主要代谢物对THs水平影响的可能机制。PBDEs及其同系物能够干扰THs的合成与分泌;因与THs结构相似,PBDEs及其代谢物能够竞争性结合THs的转运蛋白,通过多种机制反馈调控脱碘酶(Dio)的活性和表达水平,与核受体结合,从而加速THs的代谢。另外,PBDEs暴露还能对促甲状腺激素(TSH)、甲状腺激素受体(TR)甚至促甲状腺激素释放激素(TRH)的水平进行调节。面对多种因素引起的THs水平变化,机体启动反馈保护机制,使机体内具有生物活性的THs水平保持稳定。

     

    Abstract: Polybrominated diphenyl ethers (PBDEs) have been widely used as additive flame retardants in electronic devices, plastic products, building materials, etc. However, a large amount of studies have demonstrated that PBDEs are a kind of persistent organic pollutants. Due to the similarity of chemical structure between PBDEs and thyroid hormones (THs), many researchers have focused on THs disruption caused by PBDEs. We summarized the epidemiological studies on the interference of PBDEs on human THs levels, and found that exposure to PBDEs was very likely to interfere with the homeostasis of THs, but the results differed, which might be closely related to their interference mechanisms. Therefore, we analyzed the possible mechanisms of PBDEs and their major metabolites on THs disruptions from four aspects:THs synthesis and secretion, transportation, activation and metabolism, and the hypothalamus-pituitary-thyroid hormone axis. PBDEs and their metabolites can interfere with the synthesis and secretion of THs. By virtue of their similar structure to THs, PBDEs and their metabolites can competitively bind to THs transporters, feedback regulate the activity and expression levels of deiodinase (Dio) through various mechanisms, and bind to nuclear receptors in order to accelerate the metabolism of THs. In addition, PBDEs exposure can also regulate thyroid stimulating hormone (TSH), thyroid hormone receptor (TR), and even thyrotropin releasing hormone (TRH) levels. Facing the changes of THs level caused by various factors, the body initiates a feedback protection mechanism to keep the level of biologically active THs stable.

     

/

返回文章
返回