胡志斌, 罗瑞, 李喆勉, 陈博璐, 汤奕舟, 洪武定, 江从元, 许恒毅. 纳米银对中枢神经系统的影响及其机制的研究进展[J]. 环境与职业医学, 2019, 36(9): 874-878. DOI: 10.13213/j.cnki.jeom.2019.19193
引用本文: 胡志斌, 罗瑞, 李喆勉, 陈博璐, 汤奕舟, 洪武定, 江从元, 许恒毅. 纳米银对中枢神经系统的影响及其机制的研究进展[J]. 环境与职业医学, 2019, 36(9): 874-878. DOI: 10.13213/j.cnki.jeom.2019.19193
HU Zhi-bin, LUO Rui, LI Zhe-mian, CHEN Bo-lu, TANG Yi-zhou, HONG Wuding, JIANG Cong-yuan, XU Heng-yi. Effects of silver nanoparticles on central nervous system and its mechanisms: A review of recent studies[J]. Journal of Environmental and Occupational Medicine, 2019, 36(9): 874-878. DOI: 10.13213/j.cnki.jeom.2019.19193
Citation: HU Zhi-bin, LUO Rui, LI Zhe-mian, CHEN Bo-lu, TANG Yi-zhou, HONG Wuding, JIANG Cong-yuan, XU Heng-yi. Effects of silver nanoparticles on central nervous system and its mechanisms: A review of recent studies[J]. Journal of Environmental and Occupational Medicine, 2019, 36(9): 874-878. DOI: 10.13213/j.cnki.jeom.2019.19193

纳米银对中枢神经系统的影响及其机制的研究进展

Effects of silver nanoparticles on central nervous system and its mechanisms: A review of recent studies

  • 摘要: 纳米银因其优良的物理、化学及生物学特性,目前已广泛应用于化妆品、纺织品和医疗卫生等领域,涉及人们日常生活的各个方面。然而纳米银粒径小,可以通过多种途径进入中枢神经系统,并且容易在其中蓄积,从而影响中枢神经系统的正常生理功能。本文归纳了纳米银进入中枢神经系统的途径,主要包括透过血脑屏障和嗅神经途径;简述了纳米银对中枢神经系统的影响,体现在对神经细胞及组织的正常生理功能的干扰和对生物个体神经行为学的影响;总结了纳米银对中枢神经系统的影响机制,集中于纳米银影响基因表达和导致细胞凋亡、引起细胞氧化应激以及破坏神经元间连接这三方面。文章最后提出纳米银对神经系统毒性作用现存的问题及日后的研究趋势,以期为其毒理学的发展提供借鉴和参考。

     

    Abstract: Due to the excellent physical, chemical, and biological properties, silver nanoparticles (AgNPs) have been widely applied in the felds of textles, cosmetcs, and health care, involving all aspects of daily life. However, AgNPs have a small particle size and can enter the central nervous system through various routes and accumulate therein, thereby affecting the normal physiological functions of the central nervous system. This paper summarized the routes of AgNPs entering the central nervous system, including passing through the blood-brain barrier and the olfactory nerve pathway; briefly described the effects of AgNPs on the central nervous system such as interfering with the normal physiological functon of nerve cells and tssues and the neurobehaviors of individual organisms; and summarized related mechanisms:affecting gene expression and causing cell apoptosis, inducing cellular oxidative stress, and destroying interneuronal connectons. Finally, the paper raised existng problems in studies linking AgNPs to neurotoxicity and future development trend, aiming to provide insights and reference for the development of AgNPs toxicology.

     

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