鲍宇, 杨晓波. 不同生物样本中14种金属暴露生物标志物的比较研究[J]. 环境与职业医学, 2021, 38(10): 1049-1056. DOI: 10.13213/j.cnki.jeom.2021.21206
引用本文: 鲍宇, 杨晓波. 不同生物样本中14种金属暴露生物标志物的比较研究[J]. 环境与职业医学, 2021, 38(10): 1049-1056. DOI: 10.13213/j.cnki.jeom.2021.21206
BAO Yu, YANG Xiaobo. Comparative study of 14 metal exposure biomarkers in biological samples[J]. Journal of Environmental and Occupational Medicine, 2021, 38(10): 1049-1056. DOI: 10.13213/j.cnki.jeom.2021.21206
Citation: BAO Yu, YANG Xiaobo. Comparative study of 14 metal exposure biomarkers in biological samples[J]. Journal of Environmental and Occupational Medicine, 2021, 38(10): 1049-1056. DOI: 10.13213/j.cnki.jeom.2021.21206

不同生物样本中14种金属暴露生物标志物的比较研究

Comparative study of 14 metal exposure biomarkers in biological samples

  • 摘要: 背景

    由于金属在体内的分布、代谢特征差异,不同生物样本中金属浓度差异较大,导致环境健康研究结果可能容易受到所选生物样本的影响。

    目的

    系统评价各种金属生物标志物在环境健康研究中应用的优先级。

    方法

    在PubMed数据库检索到从建库至2021年3月13日发表的与8种生物样本(全血、血/红细胞、血清、血浆、尿液、头发、指/趾甲、唾液)中有毒金属(铝、砷、镉、铬、汞、镍、铅、锑)和必需元素(钴、铜、铁、锰、钒、锌)内外暴露相关的研究分别有26 073和12 948篇,经筛选最终纳入295和105篇研究。提取和归纳评价指标,根据优序图法确定评价指标的权重系数,计算各暴露生物标志物的加权优序数,以加权优序数大小对各暴露生物标志物进行排序。

    结果

    与其他生物样本比较时,全血中铬(0.872)、铅(1.000)、钴(0.863)、钒(0.815),血/红细胞中锰(0.816),尿液中铝(0.866)、砷(0.833)、镉(0.851)、汞(0.828)、镍(0.915)、锌(0.823),头发中锑(0.841)、铁(1.000)和指/趾甲中铜(0.776)的加权优序数最大。

    结论

    在环境健康研究中,全血可能适于测定铬、铅、钴和钒的浓度,血/红细胞可能适于测定锰的浓度,尿液可能适于测定铝、砷、镉、汞、镍和锌的浓度,头发可能适于测定锑和铁的浓度,而指/趾甲可能适于测定铜的浓度。

     

    Abstract: Background

    Due to the differences in the distribution and metabolism characteristics of metals in human body, the metal concentrations in different biological samples are quite different, and environmental health research results may be easily affected by the selected biological samples.

    Objective

    This study aims to systematically evaluate the priority of various metal biomarkers in environmental health research.

    Methods

    We searched PubMed database for 26 073 and 12948 studies on internal and external exposure to toxic metals (aluminum, arsenic, cadmium, chromium, mercury, nickel, lead, and antimony) and essential elements (cobalt, copper, iron, manganese, vanadium, and zinc) in eight groups of biological samples (whole blood, blood/red blood cells, serum, plasma, urine, hair, fingernail/toenail, and saliva) published from the establishment of the database to March 13, 2021. After screening, 295 and 105 studies were included. The evaluation indexes were extracted and summarized. According to the method of superiority chart, the weight coefficients of evaluation indexes were determined, weighted optimum order numbers of the selected exposure biomarkers were calculated, and the exposure biomarkers were ranked by the weighted optimum order numbers.

    Results

    The highest weighted optimum order numbers were chromium (0.872), lead (1.000), cobalt (0.863), and vanadium (0.815) in whole blood, manganese (0.816) in blood/red blood cells, aluminum (0.866), arsenic (0.833), cadmium (0.851), mercury (0.828), nickel (0.915), and zinc (0.823) in urine, antimony (0.841) and iron (1.000) in hair, and copper (0.776) in fingernail/toenail when compared with other groups of biological samples.

    Conclusion

    In environmental health research, whole blood may be suitable for determining concentrations of chromium, lead, cobalt and vanadium, blood/red blood cells for determining concentrations of manganese, urine for determining concentrations of aluminum, arsenic, cadmium, mercury, nickel and zinc, hair for determining concentrations of antimony and iron, and fingernail/toenail for determining concentrations of copper.

     

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