上海市手足口病重症病例发病危险因素研究
Study on Risk Factors Associated with Severe Case of Hand-Foot-Mouth Disease(HFMD) in Shanghai
-
摘要:
目的 掌握上海市手足口病重症病例的发病危险因素,为采取针对性干预措施,降低重症病例的发生提供依据。 方法 按照1:2 比例对73 例手足口病重症病例和146 例普通病例进行配对病例对照调查,采用Cox 回归模型进行相关危险因素的单因素和多因素分析。 结果 在环境行为因素方面,家中有同住儿童和发病前1 个月内有呼吸道感染病史的重症病例的发病风险分别是对照组的2.08 倍和3.66 倍;在临床症状体征因素方面,发热持续1~2 d、3 d及以上和EV71 感染的重症病例的发病风险分别是对照组的22.08 倍、142.63 倍和15.16 倍。 结论 家中有同住儿童可提高重症病例的发病风险,发热时间和EV71 感染可作为手足口病重症病例的早期识别指标。 Abstract:Objective To recognize the risk factors of severe cases of hand-foot-mouth disease(HFMD)in Shanghai, and to seek out clues for targeted interventions to prevent the occurrence of severe cases. Methods A total of 73 severe cases and 146 mild cases of HFMD were enrolled according to the ratio of 1:2 in this matched case-control study. Relevant information was collected and analyzed by Cox regression model with univariate and multivariate respectively. Results In terms of the environmental and behavioral factor, the risk of developing severe cases with additional children living together at same home and having history of respiratory tract infection within one month before onset was 2.08 and 3.66 times of mild cases respectively. In terms of the factors related to clinical feature, the risk of developing severe cases with fever duration of 1-2 days, more than 3 days and EV71 infection was 22.08, 142.63 and 15.16 times of mild cases respectively. Conclusion It was concluded that having additional children living together at same home increased the chance of enterovirus infection. Fever duration and EV71 infection could be used as the initial indicators to identify severe cases.
下载:
