虞慧婷, 杨青, 韩明, 宋桂香, 蔡任之, 靳文正, 王春芳. 2011年上海市新生儿先天性心脏病影响因素的病例对照研究[J]. 环境与职业医学, 2012, 29(10): 608-611.
引用本文: 虞慧婷, 杨青, 韩明, 宋桂香, 蔡任之, 靳文正, 王春芳. 2011年上海市新生儿先天性心脏病影响因素的病例对照研究[J]. 环境与职业医学, 2012, 29(10): 608-611.
YU Hui-ting , YANG Qing , HAN Ming , SONG Gui-xiang , CAI Ren-zhi , JIN Wen-zheng , WANG Chunfang . A Case-Control Study on Influencing Factors of Congenital Heart Disease in Neonates in Shanghai,2011[J]. Journal of Environmental and Occupational Medicine, 2012, 29(10): 608-611.
Citation: YU Hui-ting , YANG Qing , HAN Ming , SONG Gui-xiang , CAI Ren-zhi , JIN Wen-zheng , WANG Chunfang . A Case-Control Study on Influencing Factors of Congenital Heart Disease in Neonates in Shanghai,2011[J]. Journal of Environmental and Occupational Medicine, 2012, 29(10): 608-611.

2011年上海市新生儿先天性心脏病影响因素的病例对照研究

A Case-Control Study on Influencing Factors of Congenital Heart Disease in Neonates in Shanghai,2011

  • 摘要: 目的 分析2011年上海市新生儿先天性心脏病(CHD)发生情况,探讨CHD相关的危险因素,为人群预防措施的制定提供科学依据。

    方法 采用病例对照研究方法,结合病史摘录和调查问卷,采集2011年上海市464例CHD患儿和1 585例非CHD对照儿童父母的孕期及孕前期生活行为和环境暴露因素等信息。对危险因素的探索采用logistic回归进行单因素和多因素分析。

    结果 2011年上海市新生儿CHD以房间隔缺损为主(29.98%),其次为动脉导管未闭(28.05%)和室间隔缺损(11.03%)。经多元logistic回归分析(χ2=116.53, P<0.000 1)发现,多胞胎妊娠、受孕时父亲年龄 ≥ 50岁、母亲未进行正规产检、母亲孕期经历负性生活事件和母亲孕期烟草暴露是CHD可能的危险因素,其OR值分别为22.65、4.60、1.31、2.52和1.62。

    结论 选择最佳生育年龄,避免不良行为习惯,保持孕期心理健康,加强孕期保健,进行正规产前检查,有利于降低CHD发生的风险。

     

    Abstract: Objective To analyze the occurrence of congenital heart disease (CHD) among neonates in Shanghai in 2011,to explore the risk factors associated with CHD,and to provide scientific basis for preventive measures.

    Methods A case-control study of CHD was conducted,combining with medical history and questionnaire,to collect information on life style and environmental factors of their parents of 464 CHD cases and 1 585 healthy neonates in Shanghai in 2011.Risk factors were determined using single-factor and multivariate logistic regression analyses.

    Results In 2011,most CHD in Shanghai were found to be atrial septal defect (29.98%),followed by patent ductus arteriosus (28.05%) and ventricular septal defect (11.03%).Multivariate logistic regression (χ2=116.53,P<0.000 1) showed that multiple pregnancy,father's age above 50 years,mothers without regular prenatal care,mothers' experiences negative life events during pregnancy,and tobacco exposure during pregnancy were the possible risk factors (OR=22.65,4.60,1.31,2.52,and 1.62,respectively).

    Conclusion Choosing the best childbearing age,avoiding bad habits,maintaining mental health,strengthening health care,and taking regular prenatal care during pregnancy would help reduce the risk of CHD in neonates.

     

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