染色体13q31.1-rs1359790多态对2型糖尿病患者血糖水平的影响
Effect of 13q31.1-rs1359790 Polymorphism on Glycemic Control of Patients with Type 2 Diabetes
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摘要:
目的 探讨染色体13q31.1-rs1359790多态对2型糖尿病患者血糖控制水平的影响。 方法 2006年10月采用随机抽样的方法调查浦东新区934例2型糖尿病患者, 2011年9-10月采用重复调查研究的方法追踪随访508例。通过问卷调查、体格检查和生化检测,了解研究对象的一般特征、膳食摄入、生理指标和血糖控制水平;采用Taqman等位基因分型试验对13q31.1-rs1359790位点进行基因分型;广义线性模型分析rs1359790位点多态与血糖控制水平的关联。 结果 所研究人群的rs1359790 G/A基因型频率为AA 0.078、AG 0.404、GG 0.518,分布符合Hardy-Weinberg平衡(P=0.971)。广义线性模型分析显示,在调整可能混杂因素后, rs1359790基因型与两次调查间糖化血红蛋白下降幅度的关联有统计学意义(P=0.031),该位点的风险等位基因G可降低糖化血红蛋白水平的下降幅度。膳食纤维摄入与染色体13q31.1-rs1359790多态对2型糖尿病患者血糖控制存在负向交互作用(P=0.016),在低膳食纤维摄入组中, AA+AG基因型患者糖化血红蛋白水平的下降幅度高于GG基因型患者(P=0.002)。 结论 染色体13q31.1-rs1359790多态对2型糖尿病患者血糖控制有影响,且膳食纤维摄入对2型糖尿病患者血糖控制的影响受该多态修饰。 Abstract:Objective To investigate the effect of 13q31.1-rs1359790 polymorphism on glycemic control of patients with type 2 diabetes mellitus (T2DM). Methods A total of 934 Chinese adults diagnosed with T2DM were randomly selected for a baseline survey in Pudong New Area of Shanghai in October 2006. A repetitive survey was carried out in 508 subjects identified in the 2006 survey from September to October 2011. The participants' general characteristics, dietary intake, physical indicators, and level of glycemic control were collected through questionnaires, physical examination, and biochemical tests. Single nucleotide polymorphisms (SNPs) of rs1359790 at 13q31.1 were genotyped by Taqman allelic discrimination assay. Generalized linear model was used to analyze the association between rs1359790 polymorphisms and glycemic control. Results The genotype frequencies of rs1359790 G/A were AA 0.078, AG 0.404, GG 0.518 and met Hardy-Weinberg equilibrium (P=0.971). The results of the generalized linear model indicated a statistically significant association of rs1359790 polymorphism with the variation of hemoglobin A1c (HbA1c) between the two surveys (P=0.031), after adjusting potential confounding factors. The risk allele G of rs1359790 could reduce the decline of HbA1c level. The intake of dietary fiber was negatively interacted with the effect of rs1359790 polymorphisms on the HbA1c level (P for interaction=0.016). Among the group of low dietary fiber in take, changes in the value of HbA1c levels in the patients with AA+AG genotype were significantly higher than those of the patients with GG genotype (P=0.002). Conclusion Chromosome 13q31.1-rs1359790 polymorphism affects glycemic control in patients with T2DM, and the effect of fiber intake on their glycemic control can be modified by the polymorphism studied.
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