Abstract: Glyphosate is one of the most commonly used herbicides all around the world. Since transgenic plants with glyphosate-resistance such as soybeans and maize are introduced, the use of glyphosate have vastly increased and stirred up public concerns over potential adverse health effects on human exposed to glyphosate in agricultural practices. The present paper summerized studies on the reporductive and developmetnal toxicities of glyphosate and related mechanisms on both human and mammals, with the aim of providing suggestions for further research.