任江萍, 沈金花, 陈文花, 沈红, 顾士康, 陆红梅. 国产和进口流行性感冒疫苗不良反应率的meta分析[J]. 环境与职业医学, 2013, 30(9): 662-667.
引用本文: 任江萍, 沈金花, 陈文花, 沈红, 顾士康, 陆红梅. 国产和进口流行性感冒疫苗不良反应率的meta分析[J]. 环境与职业医学, 2013, 30(9): 662-667.
REN Jiang-ping , SHEN Jin-hua , CHEN Wen-hua , SHEN Hong , GU Shi-kang , LU Hong-mei . Meta Analysis on Adverse Reaction of Domestic and Imported Influenza Vaccines[J]. Journal of Environmental and Occupational Medicine, 2013, 30(9): 662-667.
Citation: REN Jiang-ping , SHEN Jin-hua , CHEN Wen-hua , SHEN Hong , GU Shi-kang , LU Hong-mei . Meta Analysis on Adverse Reaction of Domestic and Imported Influenza Vaccines[J]. Journal of Environmental and Occupational Medicine, 2013, 30(9): 662-667.

国产和进口流行性感冒疫苗不良反应率的meta分析

Meta Analysis on Adverse Reaction of Domestic and Imported Influenza Vaccines

  • 摘要: 目的 评价国产和进口流行性感冒(简称流感)疫苗的不良反应率。

    方法 通过文献检索搜集中国学术期刊全文数据库(CNKI)、万方数据库、中国生物医学文献数据库及维普资讯-中文科技期刊数据库中2012 年9 月前发表的有关国产流感疫苗与进口流感疫苗不良反应研究的文献,利用Stata10.0 软件进行meta 分析。

    结果 共有21篇符合标准的文献纳入本次研究。Meta 分析结果显示国产与进口流感疫苗间全身不良反应率的RR 及其95%CI 为0.897(0.751~1.073),局部不良反应率的RR 及其95%CI 为0.995(0.851~1.165),差异均无统计学意义。进一步的亚组分析结果显示:在以葛兰素史克流感裂解疫苗和巴斯德流感裂解疫苗为对照的研究中,国产流感疫苗与其之间的全身不良反应率的RR 及其95%CI 为葛兰素史克:0.990(0.622~1.577);巴斯德:0.879(0.726~1.066);局部不良反应的RR 及其95%CI 为葛兰素史克:1.002(0.779~1.287);巴斯德:0.997(0.817~1.216),差异均无统计学意义。

    结论 国产和进口流感疫苗的不良反应率差异无统计学意义。

     

    Abstract: Objective To evaluate the adverse reaction of domestic and imported influenza vaccines.

    Methods Pulished studies that compared the adverse reaction between domestic and imported influenza vaccines before September 2012 were retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Datebase, China Biology Medicine disc, and VIP China Scientific Journal Datebase. A meta analysis was performed with Stata 10.0 software.

    Results A total of 21 studies that met inclusion criteria were included in this review. A meta analysis result showed that the pooled RR (95%CI) was 0.897 (0.751-1.073) for systematic vaccine reaction between domestic and imported influenza vaccines, the pooled RR (95%CI) for local vaccine reaction between domestic and imported influenza vaccines was 0.995 (0.851-1.165), and there were no statistical differences. Further stratified analysis indicated that the pooled RRs (95%CI) for systematic vaccine reaction between domestic and imported influenza vaccines were 0.990 (0.622-1.577) for Glaxo Smith Kline and 0.879 (0.726-1.066) for Pasteur; the pooled RRs (95%CI) for local vaccine reaction between domestic and imported influenza vaccines were 1.002 (0.779-1.287) for Glaxo Smith Kline and 0.997 (0.817-1.216) for Pasteur, and no statistical difference was found.

    Conclusion There are no differences between the adverse reaction of domestic and imported influenza vaccines.

     

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