ZHANG Zhuang, CAO Li-min, CHEN Wei-hong. Research progress on PCDD/Fs-induced cardiovascular damage and related mechanisms[J]. Journal of Environmental and Occupational Medicine, 2019, 36(11): 1024-1030. DOI: 10.13213/j.cnki.jeom.2019.19257
Citation: ZHANG Zhuang, CAO Li-min, CHEN Wei-hong. Research progress on PCDD/Fs-induced cardiovascular damage and related mechanisms[J]. Journal of Environmental and Occupational Medicine, 2019, 36(11): 1024-1030. DOI: 10.13213/j.cnki.jeom.2019.19257

Research progress on PCDD/Fs-induced cardiovascular damage and related mechanisms

  • Polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans (PCDD/Fs) are persistent organic pollutants derived from anthropogenic activities and industrial processes, and can be bio-magnified through food chain and bio-accumulate in human bodies, causing various adverse health effects, including cardiovascular impairments. Cardiovascular diseases have been the leading cause of death in China and across the world. Focusing on cardiovascular toxicity of PCDD/Fs, related epidemiological and toxicological studies were reviewed in the present paper. First, epidemiological studies showed associations between PCDD/Fs exposure and the incidence/prevalence and mortality rates of hypertension, ischemic heart disease, and other adverse cardiovascular outcomes. Second, toxicological studies showed that PCDD/Fs caused atherosclerosis formation and changes of blood pressure levels, myocardial structure, and cardiac contractility. Last, previously proposed mechanisms on the cardiovascular toxicity of PCDD/Fs included activating aryl hydrocarbon receptor, oxidative stress, or inflammation, and disturbing lipid metabolism. Above summaries indicated that PCDD/Fs exposure would induce adverse effects on the cardiovascular systems of animals and humans, and elevate the risk of cardiovascular diseases. However, the specific mechanisms remain to be elucidated.

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