WANG Xin, ZHANG Xingguang, GAO Chenghua, FANG Xin. Effect of short-term atmospheric PM2.5 exposure on cardiovascular mortality in China: A meta-analysis[J]. Journal of Environmental and Occupational Medicine, 2021, 38(1): 17-22. DOI: 10.13213/j.cnki.jeom.2021.20384
Citation: WANG Xin, ZHANG Xingguang, GAO Chenghua, FANG Xin. Effect of short-term atmospheric PM2.5 exposure on cardiovascular mortality in China: A meta-analysis[J]. Journal of Environmental and Occupational Medicine, 2021, 38(1): 17-22. DOI: 10.13213/j.cnki.jeom.2021.20384

Effect of short-term atmospheric PM2.5 exposure on cardiovascular mortality in China: A meta-analysis

  • Background Fine particulate matter (PM2.5), the main pollution component of atmospheric particulate matters, is closely related to the occurrence and development of cardiovascular disease.
    Objective This study is designed to investigate the short-term effect of atmospheric PM2.5 concentration on cardiovascular mortality in China.
    Methods The databases of Wanfang, VIP, China National Knowledge Infrastructure, and PubMed were searched for the literature reporting a relationship between PM2.5 concentration and cardiovascular disease mortality in China since January 1, 2000-April 22, 2020 using fine particulate matter, ambient particulate matters, cardiovascular disease, and mortality as key words in either Chinese or English. The percentage of cardiovascular disease mortality (ER) with each increase of 10 μg·m-3 PM2.5 was used as the effect index. A short-term effect was defined as < 7 d continuous exposure to any index pollutant. Stata 15.0 software was used for meta-analysIs.
    Results A total of 581 articles were retrieved, and 18 articles were finally included according to inclusion and exclusion criteria. The random effect model showed that for every 10 μg·m-3 increase in PM2.5, the mortality rate of cardiovascular disease increased by 0.51% (95% CI:0.37%-0.65%), I2=80.2%. After subgrouping PM2.5 annual average concentrations, the heterogeneity of the concentration ≥ 75 μg·m-3 group decreased significantly, and the heterogeneity results of the subgroups of different methods and lag effects and the sensitivity test results were found no significantly change. Egger's test results indicated publication bias (P < 0.05).
    Conclusion Higher PM2.5 concentrations may increase the mortality of cardiovascular disease.
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