Objective To identify the characteristics and impact factors of recent tuberculosis in Putuo District, Shanghai, and to provide basis for making control measures against tuberculosis.
Methods Isolates of Mycobacterium tuberculosis were collected from all tuberculosis patients registered to designated tuberculosis hospitals in Putuo District from 2009 to 2010. Variable number tandem repeats (VNTR) genotyping was used to identify clustered and unique isolates. Univariate and multivariate analyses were performed to describe the distribution of the clusters and to identify demographic, clinical, and social factors associated with recent transmission of tuberculosis.
Results This study enrolled 180 patients, and the isolates from 153 patients (85.00%) belonged to Beijing genotyping strains. Totally, 20 clusters (26.67%) (48 isolates) and 132 unique isolates were identified. There were 65.00% (13/20) of the clusters infected both registered local residents and migrants. The patients of two clusters were proved to have epidemiologic links of family members' contact, and the patients of eight clusters lived in the same communities. The patients who were aged 30-59 years (versus 18-29 years, OR=3.783, 95%CI:1.421-10.074) and being infected with Beijing genotyping strains (versus non-Beijing genotyping strains, OR=6.446, 95%CI:1.446-28.731) were more likely to be clustered.
Conclusion It is speculated that recent transmission of tuberculosis exists between migrants and local residents in Putuo. Beijing genotyping strains are predominant strains in the district. Considering the related impact factors and demographic characteristics, migrant patients should be the target population for tuberculosis control in the district.
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