Research Advance on Genomic Imprinting and Spermatogenesis Dysfunction

Genomic imprinting is a mechanism that regulates monoallelic gene expression in a parental origin-dependent way. Spermatogenesis is a highly complex and unique differentiation process that involves development of spermatogonia into spermatocytes, formation of haploid spermatid, and maturation of spermatozoa. This review aimed to discuss the relationship between spermatogenesis disorder and genomic imprinting, evaluate the potential risks of epigenetic defects in the infertile men, and provide theoretical evidence for clinical treatment of male infertility.