Research Progress on Neurodevelopmental Toxicity of Paraquat

Paraquat is one of the most widely used herbicides across the world. Its acute and chronic neurotoxicity have long been concerned. Recently, its neurodevelopmental effect receives increasing attentions. This review, based on recent domestic and international literatures on paraquat's developmental neurotoxicity, summarizes results of epidemiological or animal studies and possible mechanisms of toxicity. In combination with our previous studies, it is tempting to propose a close relationship between paraquat's neurodevelopmental toxicity and Parkinson's disease, which should be more widely concerned.