Objective To establish a bronchoalveolar lavage fluid residual volume prediction model for pneumoconiosis patients by large volume whole lung lavage with transbronchoscope, and provide reference for screening potential patients for lung la vage and preliminary forecast of lavage treatment efficacy.
Methods A total of 238 patients with pneumoconiosis were enrolled in this study and received large volume whole lung lavage via transbronchoscope. The associations of residual volume with patient's pathological stage, lavage volume, lung function, height, body weight, and body mass index were analyzed by multivariate linear regression model.
Results The residual volume of large volume whole lung lavage via transbronchoscope showed no correlation with pneumoconiosis stage and no statistically significant difference across pneumoconiosis stages (P > 0.05). Lavage volume, forced vital capacity (FVC%), and maximal expiratory flow at 50% respiratory function (MEF50) were the factors affecting residual volume.
Conclusion The prediction model of residual volume of bronchoalveolar lavage fluid in pneumoconiosis patients by whole lung lavage via transbronchoscope could preliminarily screen patients for lung lavage and predict lung lavage curative effect.
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