Research progress on association between ambient air pollution and congenital heart disease
-
Abstract
Epidemiological studies show that ambient air pollution may affect the growth of fetus. In recent years, the potential impacts of exposure to air pollutants during pregnancy on adverse outcomes attract increasing attention, among which the relationship between air pollutants and congenital heart disease is an important research topic. Studies have preliminarily proved that exposure to certain pollutants during pregnancy is related to congenital heart disease, but the evidence is limited and there is no definite effect of exposure to specific air pollutant on specific congenital heart disease subtype, thus relevant assessment frameworks are warranted. This paper reviewed research progress on this issue in four aspects-exposure assessment, exposure index, quantitative method, and dose-response relationship, which comprised the framework of risk assessment of exposure to air pollution on congenital heart disease. This paper also analyzed the shortcomings of published studies on pollutant exposure assessment methods, dose-response quantification, and quantitative index selection, aiming to establish a unified and accurate assessment method of pollutant exposure, define pollutant exposure levels and exposure risk estimates, improve traditional quantitative methods, and objectively assess the dose-response relationship between air pollutant exposure and congenital heart disease. Finally, problems in this field and research trends were probed. We look forward to figure out guidelines for assessing the effects of air pollution on congenital heart disease, and provide scientific references to prevent congenital heart disease and reduce child mortality.
-
-
DownLoad: