Roles and mechanisms of RNA m6A modification in female reproductive health
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Abstract
Female reproductive health has received increasing attention, and studies on its influencing factors have also gradually increased. Epigenetic phenomenon N6-methyladenosine (m6A) is a RNA modification that is dynamically reversible within cells and regulates various life processes. In recent years, more and more studies have shown that it is closely related to female reproductive diseases, which in turn affects women's reproductive health. This review summarized the proposed roles and mechanisms of m6A modification in female reproductive process, and introduced m6A RNA regulation of reproductive and development process through methyltransferase, demethylase, or methyl binding protein, including oocyte maturation and the embryonic development of nervous system, myogenesis, and hematopoietic system, as well as its association with premature ovarian failure and cervical cancer. This paper pointed out that with the development of RNA epitranscriptomics, studies on m6A modification have shifted from a single reproductive function to a combination of mechanisms, functions, and associations with diseases; however, studies on the roles and mechanisms of m6A RNA in female reproductive health hazards due to environmental or occupational factors are still insufficient. m6A RNA may serve as a new biomarker and clinical therapeutic target, providing new ideas for protecting female reproductive health.
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