Research progress on mitophagy induced by nanomaterials
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Abstract
With the development of nanotechnology, nanomaterials are increasingly used in biomedicine, material, chemical, and other fields, providing more effective means for clinical medical applications such as bioimaging, nanodrug, and disease treatment. However, the potential occupational exposure risks and health hazards in the nano-industry pose new challenges to occupational health. In recent years, the association between nanomaterial and autophagy has gradually been revealed. Mitophagy, as a selectve autophagy, is a way for cells to selectively remove redundant or damaged mitochondria. It plays an important role in regulatng mitochondrial number and maintaining mitochondrial functons and cell homeostasis, and determines cell survival or death. Abnormal activation of mitophagy is closely related to various diseases. This review summarized the molecular regulaton mechanisms of mitophagy, and illustrated the roles of mitophagy in the biological effects of nanomaterials and its possible mechanisms. Current studies have found three main pathways for mitophagy, and the mitophagy induced by nanomaterials is mainly mediated by PINK1/Parkin signaling pathway. PINK1/Parkin signaling pathway mediated mitophagy might be one of the major mechanisms involved in the regulaton of cellular stress induced by nanomaterials, and is also one of the important protectve mechanisms for cells to resist nanomaterials-induced damage.
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