Mitochondria-related mechanisms of hepatic local innate immune response induced by xenobiotics
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Abstract
As one of the most important metabolic organs for xenobiotcs, liver equips with a unique structure of sinusoids and various subsets of immune cells, forming a hepatic local immune microenvironment. Among them, hepatic innate immune cells not only participate in host defense via pathogen clearance and antgen presentaton, but also contribute to acute immune response, sequelae of hepatotoxicity, chronic liver injury, and carcinogenesis through the interactions with hepatocytes after xenobiotic exposure. Mitochondrion, a targeted organelle of cellular stress, is a molecular platorm for integratng immune signals, which fnely regulates cellular events by mitochondrial quality control and mediates cellular communication via mitochondrial damage-associated molecular paterns to regulate the immune microenvironment. This review summarized the composition of innate immune cells and the immune cascade mediated by hepatic local immunity, and elucidated the mitochondria-related mechanisms of hepatc local immunity induced by xenobiotcs, aiming to provide clues for screening biomarkers of hepatc local immunity and making targeted interventons against liver injury.
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