Objective To observe the effect of Saussurea Medusa Maxim (SMM) on immune function of mice with exercise-induced fatigue and discuss the mechanism of its anti-fatigue.
Methods Male BALB/c mice were randomly divided into a control group and 2 experiment groups, i.e. the exercise-induced fatigue group and the exercise-induced fatigue+SMM group. The chronic fatigue model was established by exhaustive swimming. Mice in the control group and in the exercise-induced fatigue group were given through gavage with 0.2 mL water while mice in the exercise-induced fatigue+SMM group with 0.1 g Saussurea Medusa Maxim every day for 14 days. The mice in experiment groups received 7 times exhaustive swimming to induce fatigue during the 15 days. On the 15th day, lymphocyte proliferation induced by ConA, plaque forming cell(PFC)and immune organ index were observed.
Results After exhaustive swimming, the lymphocyte proliferation induced by ConA, the plaque forming cells and immune organs index in both experiment groups were lower than those in the control group(P<0.01), while those indices in the exercise-induced fatigue+SMM group were higher than those in the exercise-induced fatigue group(P<0.01).
Conclusion Saussurea medusa maxim can obviously improve the immune function of mice with exercise-induced fatigue. It has an effect of resisting exercise fatigue.
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