Objective To research the effects of sulfite on immunologic system in Kunming mice.
Methods The experiment animals were divided randomly into 4 groups:high dose group, medium dose group, low dose group and the control group. Each test group was conducted by gavage with sodium sulfite every day for 14 d and the control group was treated with physiological saline in the same volume as the exposure groups. The doses of sulfite for the 3 exposure groups were 30.00, 14.49 and 7.00 mg/kg body weight separately. Then all mice were sacrificed, the index of blood carbon expurgation, the index of thymus and the index of spleen were detected. Thymus and spleen sliced specimens were prepared for pathological observation.
Results It showed great difference in the index of carbon particle expurgation between the high, medium exposure groups and the control group (P < 0.08), but there was little difference between the low dose group and the control group. The index of thymus/spleen of high and middle dose groups also showed high significant difference than the control group (P < 0.05), but there was little difference between the low dose group and the control group.
Conclusion Sodium sulfite has an inhibiting effect on immunologic system in mice.
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