罗杭君, 卞倩. 环状RNAs在环境暴露所致肺部疾病中的作用及机制[J]. 环境与职业医学, 2022, 39(12): 1430-1437. DOI: 10.11836/JEOM22014
引用本文: 罗杭君, 卞倩. 环状RNAs在环境暴露所致肺部疾病中的作用及机制[J]. 环境与职业医学, 2022, 39(12): 1430-1437. DOI: 10.11836/JEOM22014
LUO Hangjun, BIAN Qian. Roles and mechanisms of circular RNAs in lung diseases caused by environmental exposure[J]. Journal of Environmental and Occupational Medicine, 2022, 39(12): 1430-1437. DOI: 10.11836/JEOM22014
Citation: LUO Hangjun, BIAN Qian. Roles and mechanisms of circular RNAs in lung diseases caused by environmental exposure[J]. Journal of Environmental and Occupational Medicine, 2022, 39(12): 1430-1437. DOI: 10.11836/JEOM22014

环状RNAs在环境暴露所致肺部疾病中的作用及机制

Roles and mechanisms of circular RNAs in lung diseases caused by environmental exposure

  • 摘要:

    环境污染物暴露是多种肺部疾病发生发展的重要因素。环状RNAs(circRNAs)是一类非编码RNA分子,在真核生物中广泛表达,并已证明在多种人类疾病的发生和进展中起着关键作用。研究表明,circRNAs与各种肺部疾病密切相关,可作为不同肺部疾病的诊断和预后生物标志物以及治疗靶标。本综述简要回顾了circRNAs的生理功能和分子作用机制,并对circRNAs在环境暴露所致肺部疾病中的调控机制进行了梳理和归纳,以期为今后相关领域的研究和应用提供参考依据。

     

    Abstract:

    Environmental exposure is an important factor in the occurrence and development of various lung diseases. Circular RNAs (circRNAs) are a class of noncoding RNA molecules, which are widely expressed in eukaryotes, and have been proved to play an important role in the occurrence and progression of a variety of human diseases. Studies have shown that circRNAs are closely related to various lung diseases, and have been used as diagnostic and prognostic biomarkers and therapeutic targets of some lung diseases. This review briefly described the physiological functions and molecular mechanisms of circRNAs, and summarized the regulatory mechanisms of circRNAs in lung diseases caused by environmental exposure, in order to provide new ideas for the research and application in related fields in the future.

     

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