挥发性有机物/半挥发性有机物暴露对哮喘的影响:流行病学研究与诊断应用综述

Associations of volatile organic compounds/semi-volatile organic compounds exposure on asthma: A review of epidemiological studies and diagnostic applications

  • 摘要: 挥发性有机物(VOCs)与半挥发性有机物(SVOCs)是室内外空气中常见的有机化合物,主要经呼吸道进入机体直接损害呼吸系统。既往研究提示VOCs/SVOCs暴露可能对支气管哮喘患病、发病及进展产生影响,但其影响程度尚不清楚。现阶段高效简便哮喘诊断、分型、发作预测的生物标志物仍不明确。本文从VOCs/SVOCs的采集与检测方法出发,总结了VOCs/SVOCs暴露与儿童/成人哮喘患病、发病及进展方面的流行病学研究证据及潜在生物学机制,展示了近年来VOCs/SVOCs在辅助哮喘诊断如鉴别哮喘与健康人群、鉴别不同哮喘表型、预测哮喘急性发作中的应用,为改善哮喘的管理现状提供科学依据。

     

    Abstract: Volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) are common organic compounds in indoor and outdoor air, and enter the human body primarily through the respiratory tract and directly damage the respiratory system. Previous studies have suggested that exposure to VOCs/SVOCs may associate with the prevalence, incidence, and progression of asthma, but the extent of the associations is still vague. Furthermore, biomarkers for efficient and simple asthma diagnosis, typing, and attack prediction remain unclear at this stage. From the perspective of the collection and detection methods of VOCs/SVOCs, this paper summarized the epidemiological associations and underlying biological mechanisms between VOCs/SVOCs exposure and the prevalence, incidence, and progression of asthma in children/adults. It also demonstrated the application of VOCs/SVOCs in recent years in assisting asthma diagnosis, such as distinguishing asthma patients from the healthy population, differentiating different asthma phenotypes, and predicting asthma acute exacerbations, aiming to provide a scientific basis for improving current asthma management.

     

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