日常生活来源的环境内分泌干扰物与妊娠期糖尿病关联的研究进展

Research progress on relationship between endocrine disrupting chemicals from daily life and gestational diabetes mellitus

  • 摘要: 妊娠期糖尿病(GDM)的发病率逐渐升高,已成为重要的公共卫生问题。环境内分泌干扰物(EDCs)是一类普遍存在的外源性化学物质,能够干扰激素合成、代谢和活性,影响内分泌稳态。人类在日常生活中广泛且持续接触来源于食品包装、塑料制品、纺织品、电子产品以及清洁产品和化妆品的各种EDCs,导致内分泌和代谢紊乱,引起肥胖、胰岛素抵抗、葡萄糖耐量受损和糖尿病等。既往研究表明EDCs暴露与GDM的发生密切相关,本文总结了来源于日常生活暴露的EDCs与GDM的关联及其潜在生物学机制,包括双酚、邻苯二甲酸酯、全氟/多氟烷基物质、有机磷酸酯、对羟基苯甲酸酯以及三氯生,以期为有效实施公共卫生干预措施以减缓和预防GDM提供科学证据。

     

    Abstract: The incidence of gestational diabetes mellitus (GDM) is gradually increasing and has become a significant public health issue. Endocrine disrupting chemicals (EDCs) are a ubiquitous class of exogenous chemical substances that can interfere with hormone synthesis, metabolism, and activity, and subsequently affect endocrine homeostasis. Humans are extensively and continuously exposed to various EDCs originating from food packaging, plastic products, textiles, electronic goods, as well as cleaning agents and cosmetics in daily life, leading to endocrine and metabolic disorders, such as obesity, insulin resistance, impaired glucose tolerance, and diabetes. Previous studies indicated a close association between EDCs exposure and the occurrence of GDM. This review summarized the correlation between daily life exposure to EDCs and GDM, along with their potential biological mechanisms, including bisphenols, phthalates, per- and polyfluoroalkyl substances, organophosphate esters, parabens, and triclosan, aiming to provide scientific evidence for supporting the effective implementation of public health intervention measures to alleviate and prevent GDM.

     

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