Abstract: Bisphenol S (BPS), a major substitute for bisphenol A (BPA), is widely used in the production of plastics, thermal paper, and epoxy resins, and is ubiquitous in air, soil, water, and food. In recent years, the safety issues of BPS have aroused deep concern from all sectors of society. This article integrated relevant research achievements both at home and abroad, elaborated the specific impacts of prenatal BPS exposure on the glucose metabolism of offspring, and explored potential mechanisms by which prenatal BPS exposure affects glucose metabolism. The research indicated that prenatal BPS exposure may have significant biological effects on the glucose metabolism of offspring. This article suggested that future research should further explore the mechanism of action of prenatal BPS exposure on the glucose metabolism of offspring and strengthen epidemiological studies to provide more compelling evidence. Meanwhile, effective measures should be taken to reduce public exposure risks, especially for pregnant women and fetuses, to mitigate the potential adverse health effects of BPS.