孕期内分泌干扰物暴露与儿童执行功能关联的研究进展

Research progress on association between prenatal exposure to endocrinedisrupting chemicals and children's executive function

  • 摘要: 近几十年来,世界范围内儿童神经发育障碍的患病率呈现上升趋势,执行功能在儿童早期发展中起着重要作用。既往研究显示环境内分泌干扰物可以通过胎盘及血脑屏障进入脑组织,影响神经系统的发育,危害儿童的执行功能发育。孕期作为育龄妇女的一个特殊时期,此时暴露于内分泌干扰物不仅会影响宫内发育,还可能会对子代出生后的健康造成深远影响。本文主要回顾了2015—2024年十年间,国内外有关孕期暴露于内分泌干扰物如邻苯二甲酸酯(PBDEs)、多溴联苯醚(PBDEs)、全氟和多氟烷基物质(PFASs)和双酚A(BPA)对子代执行功能影响的研究文献,并进一步探讨其背后潜在的生物学机制。多数研究指出孕期内分泌干扰物可能通过引发神经炎症、神经递质紊乱、胎盘功能障碍等形式来影响儿童的执行功能。具体而言,孕期暴露于PBDEs、PBDEs与儿童执行功能下降相关,PFASs、BPA的影响尚不明确。这些研究结果提示,未来需开展更多的流行病学研究和动物实验,以深入探讨孕期内分泌干扰物暴露对儿童执行功能的影响及其潜在的因果机制,为预防儿童神经发育障碍提供新思路,也为儿童的健康发展保驾护航。

     

    Abstract: In recent decades, the prevalence of neurodevelopmental disorders in children has been on the rise worldwide, and executive function plays an important role in early childhood development. Previous studies have shown that environmental endocrinedisrupting chemicals can enter brain tissue through the placental and blood-brain barriers, affecting neurodevelopment and jeopardizing children’s executive function development. During pregnancy, a special period for women of reproductive age, exposure to endocrinedisrupting chemicals not only affects intrauterine development, but may also have far-reaching effects on offspring health after birth. This article focused on reviewing domestic and international research literature on the effects of exposure to endocrinedisrupting chemicals e.g., phthalates, polybrominated diphenyl ethers (PBDEs), perfluorinated and polyfluorinated alkyl substances (PFASs), and bisphenol A (BPA) during pregnancy on offspring executive function published from 2015 to 2024, and further exploring potential associated biological mechanisms. Most studies pointed that endocrinedisrupting chemicals during pregnancy may affect children's executive function through triggering neuroinflammation, neurotransmitter disruption, and placental dysfunction. Specifically, exposure to phthalates and PBDEs during pregnancy is associated with reduced executive function in children, and the effects of PFAS and BPA are unclear. These findings suggest that more epidemiological studies and animal experiments need to be conducted in the future to deeply explore the effects of endocrinedisrupting chemicals exposure during pregnancy on children's executive function and its potential causal mechanisms, so as to provide new ideas for preventing neurodevelopmental disorders in children and promoting healthy development of children.

     

/

返回文章
返回