Abstract: Bisphenol A (BPA), with weak estrogenic and anti-androgenic effects, is a kind of environmental endocrine disrupting chemicals (EDCs). In recent years, the effects of BPA on reproductive system have been widely studied, including disrupting sexual differentiation, sexual maturity, gamete production, and steroidogenesis. Kisspeptin, a polypeptide encoded by KiSS-1 gene, is able to regulate reproductive function through hypothalamic-pituitary-gonadal axis. Studies have reported that kisspeptin system may be a potential target of EDCs to disrupt sexual development and reproduction. Based on the effects of BPA on reproductive system, the regulation of kisspeptin on reproduction, and the roles of sexual hormones in the regulation, this review summarized the effects of BPA on kisspeptin system, aiming to provide insights for further studies on the potential mechanism and targets through which BPA disrupts reproductive system.