Objective To examine the possible renal oxidative damage of joint exposure to formaldehyde andtrichloroethylene in mice.
Methods Totally 108 healthy Kunming inbred strain mice were randomly divided into ninegroups,each with half male and half female:a control group (clean air),two formaldehyde treatment groups (1 mg/m3,5 mg/m3),twotrichloroethylene treatment groups (1 000 mg/m3,5 000 mg/m3),and four joint treatment groups of formaldehyde and trichloroethylene (1 mg/m3+1 000 mg/m3,1 mg/m3+5 000 mg/m3,5 mg/m3+1 000 mg/m3,5 mg/m3+5 000 mg/m3,respectively).The mice were exposedto formaldehyde and/or trichloroethylene (except the controls) by static inhalation for 14 days,2 hours per day,then neutralized onthe 15th day.Total antioxidant capacity (T-AOC),glutathione (GSH),superoxide dismutase (SOD),and malondialdehyde (MDA) in the renal samples of the mice were determined.
Results The contents of GSH and the activities of T-AOC and SOD weredecreased,and the contents of MDA was increased along with the increasing of formaldehyde and/or trichloroethylene (P<0.05).There was an interaction between formaldehyde and trichloroethylene exposures on T-AOC of female mice (P<0.05).
Conclusion Inhaling formaldehyde and/or trichloroethylene can induce oxidative damage in renal of mice.The joint exposure to formaldehydeand trichloroethylene may exhibit antagonistic effect on oxidative damage in renal.
DownLoad: