Advance on Relationship among Oxidative Stress, Heat Shock Proteins, and Immunity

Oxidative stress can increase the synthesis of heat shock proteins (HSPs). Acting as molecular chaperones, HSPs protect and regulate internal homeostasis, and they also participate in innate immunity and adaptive immunity. To remove pathogens, damages may be done to immune system by oxidation reaction but can be partially repaired by HSPs and other molecular mechanisms. Severe oxidation reaction can also lead to pathological reactions. This review systemically summarized literatures on the relationship among oxidative stress, HSPs, and immunity to reveal their significance in prevention and treatment of diseases.