Objective To compare the intervention effects of nano selenium and sodium selenite on oxidative damage in selected mouse tissues induced by high iodine.
Methods Forty-eight male Kunming mice were divided into four groups:normal io dine group (50 µg/L KIO3), high iodine group (3 000 µgL KIO3), sodium selenite group (3 000 µg/L KIO3 plus 0.193 mg/kg Se), nano selenium group (3 000 µg/L KIO3 plus 0.193 mg/kg Se). Four weeks later, glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum, liver, and kidney were determined. Pathological changes of thyroid were also observed.
Results Compared with the normal iodine group, in the high iodine group, the GSH-Px activities in serum, liver, and kidney were reduced (P<0.05); the MDA content in liver was also lowered (P<0.05); the tissue organ coefficients of liver and kidney were elevated (P<0.05). Compared with the high iodine group, in the sodium selenite group, the GSH-Px activities in liver and serum were increased (P<0.05); the MDA content in kidney was increased (P<0.05); the organ coefficient of liver tissue was decreased (P<0.05). In the nano selenium group, compared with the high iodine group, the GSH-Px activities in liver, kidney, and serum were increased (P<0.05); the MDA contents decreased significantly in liver and serum, but increased significantly in kidney (P<0.05); the organ coefficient of kidney tissue decreased significantly (P<0.05). The mice in the high iodine group showed colloid goiter.
Conclusion High iodine in take may result in oxidative damage in mice, and selenium supplementation could exert favorable effects on it. Intervention effect of nano selenium is better than that of sodium selenite.
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