Objective To assess the health risks of air fine particulate matters(PM2.5) based on meta-analysis and establish an exposure-response relationship between PM2.5 and daily mortality in residents of China.
Methods An online research via Medical Periodical Database of Medicine Information System, Conference Papers, Dissertations Digital Library, VIP Database for Chinese Technical Periodicals, Chinese National Knowledge Infrastructure(CNKI), PubMed/Medline was conducted using key words “PM2.5” and “daily death”, “exposure-response relationship”, combining manual searching in relevant journals. Then 54 literatures published from January 2003 to January 2015 met the above requirements. Finally, relative risks(RR) of daily mortality in association with a 10-μg/m3 increase were included in the study to perform meta-analysis by Stata 12.0 software. A fixed or random effect model combining effect values was used to perform sensitivity analysis and adjust publication bias.
Results A total of 14 original literatures and 19 sets of data were included, and after excluding heterogeneous data 12 eligible literatures and 13 sets of data were valid. After adjusting publication bias, within the concentration range of 14.34-405.0 μg/m3, a 10-μg/m3 increase of PM2.5 was associated with an estimated RR of daily mortality at 1.002 6(95% CI: 1.001 5-1.004 0). After excluding heterogeneous data, in the PM2.5 concentration range of 14.34-292.3 μg/m3, the RR of total daily mortality due to PM2.5 was 1.003 7(95% CI: 1.002 7-1.004 9).
Conclusion The meta-analysis concludes that the increase of PM2.5 concentration in the range of 14.34-292.3 μg/m3 might lead to the increase of total daily mortality of residents in China.
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