Current neurotoxicity research on perfluorooctane sulfonate
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Graphical Abstract
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Abstract
Perfluorooctane sulfonate (PFOS) as an extremely persistent and refractory organic pollutant has attracted increasing attention from researchers in various fields in recent years. This paper reviewed PFOS transport and metabolism, neurotoxicity, and possible mechanisms, including inhibiting neuron growth & differentiation and brain development, affecting synaptogenesis and plasticity, suppressing neurotransmitter production, disturbing ion channels, and inducing neuroinflammation & oxidative stress in neuron cells.
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