Research progress on oxidative stress related mechanism of asbestos cytotoxicity
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Graphical Abstract
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Abstract
Asbestos is closely associated with asbestosis, pleural plaques, lung cancer, and malignant mesothelioma; however, their pathogenic mechanisms have not been fully elucidated. The accumulation of reactive oxygen species induced by asbestos fibers or the lack of antioxidants can cause oxidation-antioxidant system imbalance, leading to a series of oxidative stress injuries, including lipid peroxidation, protein denaturation, DNA damage, and enzyme activity alterations, which is one of the potential pathogenesis of asbestos. Further studying the production of reactive oxygen species and the molecular mechanism of oxidative stress injury may provide new ideas for the prevention, diagnosis, and treatment of asbestos exposure related diseases.
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