Research progress on neuro-immune toxicity of paraquat
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Graphical Abstract
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Abstract
Paraquat is a widely used herbicide with moderate toxicity to human. According to available epidemiological data, paraquat can in crease the risk of central nervous system degenerative diseases such as Parkinson's disease by chronic low-dose administration. In this paper, a systematic review summarized the immune response involved in central nervous system injury induced by paraquat, in cluding immune disorder of central nervous system and neuroinflammation induced by paraquat, neuroinflammation development associated with neurological damage induced by paraquat, and neuroinflammation induced by paraquat and regulated by multiple factor networks, aiming to provide a theoretical basis for further study of the mechanism of neuro-immune toxicity of paraquat and future drug intervention.
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