Research progression on N6-methyladenosine related proteins and their regulation to noncoding RNAs
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Graphical Abstract
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Abstract
N6-methyladenosine (m6A), abundant in eukaryotic RNAs, refers to methylation of the adenosine base at the nitrogen-6 position. m6A has been recognized to be regulated by three categories of proteins, of which methyltransferases catalyze the formation of m6A modification, demethylases erase m6A markers from RNA, and methyl-binding proteins selectively recognize m6A modification. In recent years, increasing research has revealed that m6A plays an important role in production and functioning of non-coding RNAs such as microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). According to the latest reports, this paper summarized the types and functions of m6A-related proteins, as well as the mechanisms of m6A regulatory proteins on the production and functioning of non-coding RNAs, aiming to provide reference for future research on m6A-related proteins and their effects on non-coding RNAs.
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