Review on mechanisms of PM_2.5 in cardiovascular system injuries

Air pollution is a major challenge to public health in China. Fine particulate matter (PM_2.5), a key component of atmospheric pollutants, is closely related to the occurrence and development of cardiovascular diseases. Therefore, based on existing in vivo and in vitro studies, this review elucidated the potential mechanisms of PM_2.5 exposure in the pathogenesis of cardiovascular diseases from the following aspects:oxidative stress, inflammation, DNA methylation, DNA damage, apoptosis, and vascular endothelial dysfunction.