Objective To investigate the correlation between serum uric acid(UA) and lipidemia profile in essential hypertensive adults with moderate- and high-risk of cardiovascular diseases.
Methods A total of 1 442 patients(male 36.27%, female 63.73%)without diabetes and target organ damage from 4 communities in Shanghai were selected by risk category. Of them, the proportion of moderate- and high-risk was 82.39% and 17.61% respectively. The serum levels of UA, triglyceride(TG), total cholesterol(TC), high density lipoprotein cholesterol (HDL-c), and low density lipoprotein cholesterol (LDL-c)were measured by automatic biochemical analyzer.
Results The prevalence of hyperuricemia was 20.2% in hypertension patients(moderaterisk 19.0%, high-risk 25.6%, χ2=5.602, P=0.018). In female patients, serum uric acid level in high-risk was higher than moderaterisk(307 μmol/L vs. 279 μmol/L, Z=-2.935, P<0.01). The average blood levels of TG was raised, and HDL-c was lowered as increasing of serum UA level. The difference between high- and moderate-risk was not significant(355 μmol/L vs 351 μmol/L, Z=-0.335, P>0.05)in male. Bivariate Spearman' rank correlate analysis showed significant correlation of serum UA with disystolic blood pressure, TG, TC, and HDL-c. Multivariate Partial correlation analysis showed that only correlation with significance was found between serum UA and TG levels(r=0.203, P<0.01).
Conclusion Serum UA in hypertension patients shows trend of parallel increament with lipidemia profile. The only independent correlation is found between serum UA and TG. The results suggest that increament of serum UA in hypertensive adults may be one of the predictors of hypertension progression.
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