Objective Using mixed chemical modifiers to improve the determination of lead in blood and urine by graphite furnace atomic absorption spectrometry.
Methods Through comparing the effects of five chemical modifiers and optimizing the test condition of graphite furnace, lead in blood and urine were determined by directly diluting.
Results A mixture of 0.2% ammonium dihydrogen phosphate and 0.05% magnesium nitrate solution was used as chemical modifier for the blood samples containing lead. A mixture of 4% ammonium dihydrogen phosphate and 6% ascorbic acid solution was used as chemical modifier for the urine samples containing lead. The linear ranges of blood and urine lead determination respectively were 3-100 μg/L and 6.7-80 μg/L respectively. The detection limits were 0.9 μg/L and 2.0 μg/L respectively. The relative standard deviations (RSD) were less than 5%. The addition standard recovery rates were 92.1%-104.0%.
Conclusion Using mixed chemical modifier to facilitate lead determination in blood or urine is sensitive, accurate and of good reproducibility, low cost, and ease to popularize. This method is suitable for the detection of bulk samples.
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